Player vs. Player

In 2002, the comic Player vs. Player by Scott Kurz featured a "public service announcement" titled "Fur Is Bad." Lead character Brent went on a rant about furries instead, describing them as "sick deviants who secretly want to have sex with animals." At which point Jade pops in and tells him that he was supposed to be speaking out against wearing fur, not furries. Although this strip was meant to be a one-shot deal, backlash from his readers inspired a followup series in which furries (all in partial costume) show up at the office to protest. They are finally scared off by Skull the troll who mistakes them for Pokémon. (The series begins here.)